The primary role of Mouse Genetics Core Facility (MGCF) is to facilitate the use of mouse molecular genetics at MSK for in vivo studies of gene functions germane to cancer. Relevant fields in which ...

After 5-10 generations of inbreeding, mouse colonies should be “refreshed”, to remove or prevent genetic drift accumulation in the colony. Several methods to refresh the genetic background may include ...

The primary goal of mouse mutagenesis programmes is to develop a fundamental research infrastructure for mammalian functional genomics and to produce human disease models. Many large-scale programmes ...

The laboratory mouse has been widely used for research on a variety of diseases and genetic studies to understand which genes are involved in various illnesses. However, actual variations in past ...

There is general appreciation that 'genetic background effects' can profoundly affect the immune phenotypes of congenic, transgenic and knockout mice. We suggest that attributing phenotypes to genetic ...